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  #1  
Old August 27th, 2017, 23:55
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Reasonable Rascal Reasonable Rascal is offline
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Exclamation Coming Soon

Just a teeny tiny itty bitty hint of what is to come. Over 400 pages in all and much better illustrated than the last endeavor. The pharm chapter is new this time, as are a few others.

RR

Penicillin V Potassium (oral tablets)


Class: Antibiotic. On the WHO List of Essential Medications.


Pharmacodynamics: Bactericidal action against penicillin-sensitive microrganisms. Weakens the developing bacterial cell wall causing the death of the organism.


Pharmacokinetics: It is excreted through the kidneys with as much as 60-80% being excreted unchanged in crystalline form.


Indications: bacterial infections such as mild to moderate pneumonia, scarlet fever and skin, ear and strep throat infections. It is considered to be the drug of choice for non-bioterrorism related anthrax infections.


Dosage(s): Adults 250 mg (400,000 units) or 500 mg (800,000 units) orally every 4 6 hours. May be taken with food but blood levels achieved are slightly higher if taken on an empty stomach.


Contraindications: severe cases of pneumonia, meningitis, arthritis, empyema or sepsis, or known allergy to medication. True anaphylactic reactions to oral penicillin are rare.


Common Side Effects: nausea, vomiting, epigastric distress or diarrhea. Mild rash is not a true allergic reaction. Can inactivate oral contraceptives during use.


Austere Production Potential: potentially very good given the right knowledge and means of production. Penicillium chrysogenum produces approximately 50,000 times more medication per volume than the original Penicillium notatum strain the drug was developed from. Not all bread or fruit molds are penicillium, and of those that are not all are the correct strain.


Tetracycline

Class: Antibiotic, classified as broad-spectrum. On the WHO List of Essential Medications.


Pharmacodynamics: Bacteriostatic, prevents replication and growth of the infecting microorganisms by interfering with protein synthesis.


Pharmacokinetics: Absorption takes place primarily in the stomach, duodenum and small intestine. Forms non-dissolvable complexes in the presence of calcium, magnesium, iron and aluminum. Meals of protein, fat or carbohydrate with reduce absorption by up to 50%; best taken on an empty stomach either 1 hour before or 2 hours after meals - for that reason. Mostly excreted by the kidney and biliary routes. Must take with at least 8 ounces of fluids for bedtime dose. Do not take with oral contraceptives.


Indications: Indicated for bacterial infections involving the skin, respiratory and urinary tracts, intestines, genitalia and other systems. It does not treat viral infections. Occasionally used when other medications such as Penicillin and others cannot be safely for a particular patient.


Dosages: 500 mg taken by mouth every 6 hours for 7-21 days depending on infection being treated.



Longer course of treatment for anthrax. Only taken twice daily for skin infections.



Common Side Effects: nausea and vomiting, diarrhea, greatly increased skin sensitivity to sunlight.


Austere Production Potential: Good, assuming possession of the right knowledge and means. Nota cottage-level endeavor but possible in a non-modern setting.


Cephalexin

Class: Antibiotic. On the WHO List of Essential Medications.


Pharmacodynamics: Effective against most Gram positive bacteria and many Gram negative microorganisms. Inhibits cell wall synthesis.


Pharmacokinetics: filtered out by the kidneys and excreted unchanged
Indications: Bone, genitourinary and respiratory, skin and subcutaneous tissue infections, and acute prostatitis.


Dosages: Usual dose for all applications is 250 mg every 6 hours by mouth, but may also be taken as 500 mg every 12 hours, normally for 7 to 14 days. Pediatric dosing is considered weight-dependent. May be given without regard to meals.


Contraindications: Known hypersensitivity to cephalosporins. Should not be administered with Probenicid.


Side Effects: Most common is diarrhea, followed by nausea and vomiting. Rash and fever may occur. Allergy seen in less than 0.1% of patients, but rises to 1 10% of patients with Penicillin allergy.


Austere Production Potential: Unlikely owing to complexity.
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Old August 28th, 2017, 05:34
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Default Re: Coming Soon

Excellent, can't wait.
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  #3  
Old August 29th, 2017, 16:31
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Default Re: Coming Soon

Final writing is done, now for the editing. There's what starts the pharm appendix:

Quote:
In this section, we provide a brief overview of common useful drugs in an austere orsurvival setting. There are thousands of different drugs andthey all have differentuses and pros and cons to their use. It is not practical orpossible to store more than adozen to couple of dozen different drugs

the cost of rotation when they expire (evenif you are prepared to use beyond their expiry date to a certa
in degree) is prohibitiveand so is the ability of the average person to obtain a large collection in the first place.We have focused on a small set of common and useful drugs (about 30) as has been discussed elsewhere in this book most common medical problems can be dealt with,with a relatively small group of drugs and we have focused on these. They are divided into:

Antibiotics

and

Other drugs

Pharmacology is the study of drugs and how they work. We break it down further into Pharmacodynamics (what the drug does to the body what it does and how it works) and pharmacokinetics (what the body does to the drug how it metabolises it, breaksit down and gets rid of it) This is a complex field and we have not gone into huge detail for each drug, the goalis to provide enough information to give you a working knowledge

we have kept descriptions of the pharmacokinetic and dynamics simple a nd only included the
common side-effects and important contraindications.
We have followed the same format providing similar information for each drug:

Name (and route of administration)

Class (type of drug it is)

Pharmacokinetics

Pharmacodynamics

Indications (when to give it)

Dosing

Contraindications and cautions (when not to give it or when to be careful)

Side-effects (the problems you sometimes see when you give it)

Austere production potential
**
** Austere production potential: This section does not detail the exact methods for manufacture this would be a book in its own right. It is an indication of thecomplexity of manufacture and how practical production inan austere or survivalsituation is. Even those drugs which are relatively easy to manufacture would require knowledge of basic chemistry, laboratory equipment and potentially pre-cursor chemicals. But we have flagged them as drugs with genuine potent ial for low-tech manufacture.
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  #4  
Old September 7th, 2017, 21:17
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Reasonable Rascal Reasonable Rascal is offline
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Default Re: Coming Soon

Latest update: We are now at 448 pages and not quite finished yet. Added another 12 pages just today written by a biomedical tech. Hopefully suturing is in the making now. Getting close, very close.

RR
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  #5  
Old September 7th, 2017, 22:14
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Default Re: Coming Soon

I'm still waiting, patiently.
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